Postdoc
P.I.- Dr. Tan Ince, Pathology, Brigham and Women's Hospital in Boston
(Req # part-00039288)
Responsibilities: Disease Area: Breast cancer, ovarian cancer and malignant mesothelioma. Research Projects: a) Tumor Stem Cell Epigenome: This is a highly collaborative project that is designed to identify breast tumor stem cell-specific histone modification and DNA-methylation patterns and map transcription factor networks that regulate tumor stem cell phenotype. b) Heat Shock Proteins (HSP): This project is designed to examine regulation of tumor stem cell biology by Heat Shock Proteins (HSP) and its influence on breast cancer phenotype in collaboration with a renowned HSP lab. c) Development of Culture Media: Our laboratory has specific expertise in developing chemically defined cell culture media specially designed to grow normal and malignant human epithelial and stem cells. d) Systematic Genotype/Phenotype Correlations: This project is designed to map the oncogenic pathways that cause malignant behavior in genetically engineered malignant mesothelioma cells. e) Analysis of Cell-of-origin/Oncogene Cooperation: This project is designed to determine the cell origin of different human breast and ovarian carcinomas. Relevant References and Publications: a. Ince TA, et al. Transformation of distinct human breast epithelial cell types leads to different tumor phenotypes. Cancer Cell 2007;12 (2):160-170. b. Team finds way to create cancer stem cells.
