Cancer Treatment Adjuvant
Ingredients
Dosage
Rationale
Reference
9
63810
Protocols
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Zinc
Saw Palmetto ( Serenoa
repens )
Pumpkin ( Cucurbita
pepo )
Pygeum ( Pygeum
africanum )
Stinging Nettle ( Urtica
dioica )
Lycopene
Take twice
daily.
15 mg
160 mg
100 mg
50 mg
50 mg
1 mg
Additional Prostate Support
Zinc is critical for proper cell growth,
proliferation, metabolism and migration1
Saw palmetto inhibits prostate cell
growth by up to 20-25% and cancer cell
growth by up to 50% ( in vitro ); also
reduces inflammation (COX-2)2
Pumpkin mildly inhibits 5-alpha
reductase (enzyme which converts
testosterone to ihydrotestosterone) ( in
vivo ); reduces inflammation; and reduces
prostate symptoms3
Pygeum improved micturition in 66%
men after two months (clinical study)4
Meta analysis of 18 randomized
controlled trials involving 1,562 men
found that men who received pygeum
extract were more than twice as likely to
report improvements; nocturia was
reduced by 19%, residual urine volume
by 24% and peak urine flow increased by
23%5
Stinging nettle improved lower urinary
tract symptoms for 81% of patients; peak
flow rate increased 2.5 times that of
placebo6
Research suggests lycopene may
decrease growth of prostate cancer7
1. Costello LC, et al. The clinical
relevance of the metabolism of
prostate cancer; zinc and
tumor suppression: connecting
the dots. Mol Cancer. 2006
May 15;5(1):17 [Epub ahead of
print]
2. Goldmann WH, et al. Saw
palmetto berry extract inhibits
cell growth and Cox-2
expression in prostatic cancer
cells. Cell Biol Int .
2 001;25(11):1117-24.
3. Zhang X, et al. Effect of the
extracts of pumpkin seeds on
the urodynamics of rabbits: an
experimental study. J Tongji
Med Univ . 1994;14(4):235-8.
4. Barlet A, et al. Efficacy of
Pygeum africanum extract in
the medical therapy of
urination disorders due to
benign prostatic hyperplasia:
evaluation of objective and
subjective parameters. A
placebo-controlled double-
blind multicenter study. Wien
Klin Wochenschr . 1990 Nov
23;102(22):667-73.
5. Ishani A, et al. Pygeum
africanum for the treatment of
patients with benign prostatic
hyperplasia: a systematic
review and quantitative meta-
analysis. Am J Med . 2000 Dec
1;109(8):654-64.
6. Safarinejad MR. Urtica dioica
for Treatment of Benign
Prostatic HyperplasiaA
Prospective, Randomized,
Double-Blind, Placebo-
Controlled, Crossover Study.
J Herb Pharmacother .
2005;5(4):1-11.
7. Kucuk O, et al. Phase II
randomized clinical trial of
lycopene supplementation
before radical prostatectomy.
Cancer Epidemiol Biomarkers
Prev . 2001;10:861-868.
Prostate Cancer
Cancer Treatment Adjuvant
Ingredients
Dosage
Rationale
Reference
10
63810
Protocols
www. protocols. integrativeinc.com
Calcium D-Glucarate
Green Tea ( Camellia
sinensis )
Maitake ( Grifola
frondosa ) Mushroom
Lycopene
Take twice
daily with
meals.
200 mg
50 mg
55 mg
2.5 mg
Calcium D-glucarate
Elevated beta-glucuronidase activity has
been associated with an increased risk
for various cancers, particularly
hormone-dependent cancers such as
breast, prostate, and colon cancers.
Calcium D-glucarate inhibits activity of 尾-
glucuronidase1,2
Green tea inhibits prostate cancer
development, progression, and
metastasis3,4
Maitake mushroom activates immune
cells and possesses anti-tumor activities5
1. Walaszek Z, et al. Metabolism,
uptake, and excretion of a
Dglucaric acid salt and its
potential use in cancer
prevention. Cancer Detect
Prev .1997;21:178-190.
2. Walaszek Z. Potential use of
D-glucaric acid derivatives in
cancer prevention. Cancer Lett
1990;54:1-8.
3. Gupta S, et al. Inhibition of
prostate carcinogenesis in
TRAMP mice by oral infusion
of green tea polyphenols. Proc
Natl Acad Sci U S A .
2001;98:10350-10355.
4. Chung LY, et al. Induction of
apoptosis by green tea
catechins in human prostate
cancer DU145 cells. Life Sci .
2001;68:1207-1214.
5. Matsui K, et al. Effects of
maitake (Grifola frondosa) D-
Fraction on the carcinoma
angiogenesis. Cancer Lett.
2001;172:193-198.
Prostate Cancer
Cancer Treatment Adjuvant
Ingredients
Dosage
Rationale
Reference
11
63810
Protocols
www. protocols. integrativeinc.com
ADDITIONAL SUPPORT FOR PROSTATE CANCER PREVENTION OR ESTROGEN DOMINANCE
Stable, Bioavailable
Diindolylmethane
(DIM), co-solubilized
with vitamin E and
phosphatidylcholine,
for enhanced
absorption and
bioavailability
30 mg daily
Estrogen Balance
Shifts estrogen metabolism to C-2
pathway in liver, which increases ratio of
2-hydroxy and 2-methoxy estrogen
metabolites over 16-hydroxyestrone
estrogen metabolites1
Exhibits potent antiproliferative and
antiandrogenic properties in androgen-
dependent human prostate cancer cells2
Also reduces intracellular and secreted
PSA levels2
1. Zeligs MA. Safer estrogen with
phytonutrition. Towns Lett .
1999;189:83-88.
2. Le HT, et al. Plant-derived 3,3'-
Diindolylmethane is a strong
androgen antagonist in human
prostate cancer cells. J Biol
Chem . 2003 Jun
6;278(23):21136-45.
Calcium D-Glucarate
0.5 - 1.5 g
three times
daily with
meals
Estrogen Detoxification
Detoxifies estrogen and xenoestrogen by
inhibiting beta-glucuronidase and
preventing hydrolysis of their
glucuronides1
1. Walaszek Z, et al. Metabolism,
uptake, and excretion of a D-
glucaric acid salt and its
potential use in cancer
prevention. Cancer Detect
Prev . 1997;21(2):178-90.
This Integrative Interventions protocol is sponsored by
Integrative Therapeutics, Inc., Green Bay, WI, 54311
www.integrativeinc.com 1-800-931-1709
Prostate Cancer
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